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8-br–cadpr  (Millipore)


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    Millipore 8-br–cadpr
    8 Br–Cadpr, supplied by Millipore, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/8-+br-+cadpr/8+br+cadpr/pm34935867-426-0-1
    Average 90 stars, based on 1 article reviews
    8-br–cadpr - by Bioz Stars, 2026-10
    90/100 stars

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    Related Articles

    other:

    Article Title: Intestinal goblet cells sample and deliver lumenal antigens by regulated endocytic uptake and transcytosis
    Article Snippet: 67292 21 of 29 Reagent type (species) or resource Designation Source or reference Identifiers Additional information Antibody Goat anti- Rabbit IgG Alexa Fluor 647 (goat polyclonal) Thermo Fisher Scientific Cat#A- 21244 RRID:AB_2535812 IF (1:1000) Chemical compound, drug Atropine Sigma- Aldrich Cat#A0257 550 μg/kg i.p. Chemical compound, drug Telenzepine Sigma- Aldrich Cat#T122 550 μg/kg i.p. Chemical compound, drug 4- DAMP Sigma- Aldrich Cat#SML0255 550 μg/kg i.p. Chemical compound, drug Tropicamide Tocris Cat#0909 100 μg/kg s.c. Chemical compound, drug Carbamylcholine Sigma- Aldrich Cat#C4382 125 μg/kg s.c. Chemical compound, drug FM 1–43 FX Thermo Fisher Scientific Cat#F35355 50 μg/ml Chemical compound, drug EGTA Sigma- Aldrich Cat#E3889 2 mM Chemical compound, drug BAPTA- AM Sigma- Aldrich Cat#A1076 200 μM Chemical compound, drug Xestospongin C Sigma- Aldrich Cat#X2628 22 μM Chemical compound, drug Dynasore Sigma- Aldrich Cat#D7693 150 μM Chemical compound, drug Dyngo 4a Selleck Chemicals Cat#S7163 120 μM Chemical compound, drug Colchicine Tocris Cat#1364 100 μM Chemical compound, drug Cytochalasin D Tocris Cat#1233 4 μM Chemical compound, drug Ciliobrevin D Sigma- Aldrich Cat#250401 100 μM Chemical compound, drug Dimethylenastron (DMEA) Tocris Cat#5261 10 μM Chemical compound, drug 8- Br- cADPr Sigma- Aldrich Cat#B5416 0.2 mg/kg i.p. Chemical compound, drug Trans- Ned19 Tocris Cat#3954 5 mg/kg i.p Chemical compound, drug LY294002 Sigma- Aldrich Cat#L9908 4 mg/kg i.p Chemical compound, drug Diamidino- 2- phenylindole (DAPI) Sigma- Aldrich Cat#D9542 1 μg/ml Chemical compound, drug UEA1 Fluorescein Vector Laboratories Cat#FL- 1061–2 10 μg/ml Chemical compound, drug WGA Fluorescein Vector Laboratories Cat#FL- 1021 10 μg/ml Chemical compound, drug WGA Texas Red Sigma- Aldrich Cat#W21405 10 μg/ml Chemical compound, drug Dextran tetramethylrodamine conjugate, lysine fixable, MW 10,000 Thermo Fisher Scientific Cat#D1817 12.5 mg/ml Continued on next page Continued Gustafsson et al. eLife 2021;0:e67292.



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    Effect of the extracellular Ca 2+ chelator EGTA, intracellular Ca 2+ chelator BAPTA-AM, IP3R inhibitor Xestospongin C (Xesto C), <t>cADPr</t> inhibitor <t>8-Br-cADPr,</t> and NAADP inhibitor Trans-Ned-19 (T Ned-19) on CCh-induced mucus secretion in ( A ) the SI villus, ( B ) the SI crypt. Effect of Ca 2+ signaling inhibitors on CCh-induced GAP formation in ( C ) the SI villus, ( D ) the SI crypt. ( E–K ) Representative images of the effect of the respective treatments on CCh-induced mucus secretion and GAP formation. Scale bar: E–K = 50 µm. Data are presented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, n.s = non-significant as compared to CCh. Vehicle and CCh, n = 7, EGTA and BAPTA-AM n = 5, Xesto C, T-Ned-19, and 8-Br-cADPr n = 6. Statistical analysis was performed using a one-way ANOVA followed by Dunnet’s post hoc test. Each data point in ( A–D ) represents the average of 25 villi or 40 crypts from one mouse.
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    Image Search Results


    Effect of the extracellular Ca 2+ chelator EGTA, intracellular Ca 2+ chelator BAPTA-AM, IP3R inhibitor Xestospongin C (Xesto C), cADPr inhibitor 8-Br-cADPr, and NAADP inhibitor Trans-Ned-19 (T Ned-19) on CCh-induced mucus secretion in ( A ) the SI villus, ( B ) the SI crypt. Effect of Ca 2+ signaling inhibitors on CCh-induced GAP formation in ( C ) the SI villus, ( D ) the SI crypt. ( E–K ) Representative images of the effect of the respective treatments on CCh-induced mucus secretion and GAP formation. Scale bar: E–K = 50 µm. Data are presented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, n.s = non-significant as compared to CCh. Vehicle and CCh, n = 7, EGTA and BAPTA-AM n = 5, Xesto C, T-Ned-19, and 8-Br-cADPr n = 6. Statistical analysis was performed using a one-way ANOVA followed by Dunnet’s post hoc test. Each data point in ( A–D ) represents the average of 25 villi or 40 crypts from one mouse.

    Journal: eLife

    Article Title: Intestinal goblet cells sample and deliver lumenal antigens by regulated endocytic uptake and transcytosis

    doi: 10.7554/eLife.67292

    Figure Lengend Snippet: Effect of the extracellular Ca 2+ chelator EGTA, intracellular Ca 2+ chelator BAPTA-AM, IP3R inhibitor Xestospongin C (Xesto C), cADPr inhibitor 8-Br-cADPr, and NAADP inhibitor Trans-Ned-19 (T Ned-19) on CCh-induced mucus secretion in ( A ) the SI villus, ( B ) the SI crypt. Effect of Ca 2+ signaling inhibitors on CCh-induced GAP formation in ( C ) the SI villus, ( D ) the SI crypt. ( E–K ) Representative images of the effect of the respective treatments on CCh-induced mucus secretion and GAP formation. Scale bar: E–K = 50 µm. Data are presented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, n.s = non-significant as compared to CCh. Vehicle and CCh, n = 7, EGTA and BAPTA-AM n = 5, Xesto C, T-Ned-19, and 8-Br-cADPr n = 6. Statistical analysis was performed using a one-way ANOVA followed by Dunnet’s post hoc test. Each data point in ( A–D ) represents the average of 25 villi or 40 crypts from one mouse.

    Article Snippet: Chemical compound, drug , 8-Br-cADPr , Sigma-Aldrich , Cat#B5416 , 0.2 mg/kg i.p..

    Techniques:

    Effect of the extracellular Ca 2+ chelator EGTA, intracellular Ca 2+ chelator BAPTA-AM, IP3R inhibitor Xestospongin C (Xesto C), cADPr inhibitor 8-Br-cADPr, and NAADP inhibitor Trans-Ned-19 (T Ned-19) on ( A ) CCh-induced mucus secretion and ( B ) GAP formation in the distal colon. ( C–I ) Representative images of the effect of the respective treatments on CCh-induced mucus secretion and GAP formation. Data are presented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, n.s = non-significant as compared to CCh. Vehicle and CCh, n = 7, EGTA and 8-Br-cADPr n = 5, BAPTA-AM, Xesto C, and T-Ned-19 n = 6. Scale bar: C–I = 50 µm Statistical analysis was performed using a one-way ANOVA followed by Dunnet’s post hoc test. Each data point in ( A–B ) represents the average of 40 crypts from one mouse.

    Journal: eLife

    Article Title: Intestinal goblet cells sample and deliver lumenal antigens by regulated endocytic uptake and transcytosis

    doi: 10.7554/eLife.67292

    Figure Lengend Snippet: Effect of the extracellular Ca 2+ chelator EGTA, intracellular Ca 2+ chelator BAPTA-AM, IP3R inhibitor Xestospongin C (Xesto C), cADPr inhibitor 8-Br-cADPr, and NAADP inhibitor Trans-Ned-19 (T Ned-19) on ( A ) CCh-induced mucus secretion and ( B ) GAP formation in the distal colon. ( C–I ) Representative images of the effect of the respective treatments on CCh-induced mucus secretion and GAP formation. Data are presented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, n.s = non-significant as compared to CCh. Vehicle and CCh, n = 7, EGTA and 8-Br-cADPr n = 5, BAPTA-AM, Xesto C, and T-Ned-19 n = 6. Scale bar: C–I = 50 µm Statistical analysis was performed using a one-way ANOVA followed by Dunnet’s post hoc test. Each data point in ( A–B ) represents the average of 40 crypts from one mouse.

    Article Snippet: Chemical compound, drug , 8-Br-cADPr , Sigma-Aldrich , Cat#B5416 , 0.2 mg/kg i.p..

    Techniques:

    Journal: eLife

    Article Title: Intestinal goblet cells sample and deliver lumenal antigens by regulated endocytic uptake and transcytosis

    doi: 10.7554/eLife.67292

    Figure Lengend Snippet:

    Article Snippet: Chemical compound, drug , 8-Br-cADPr , Sigma-Aldrich , Cat#B5416 , 0.2 mg/kg i.p..

    Techniques: Plasmid Preparation, Sequencing, Software

    Effect of the extracellular Ca 2+ chelator EGTA, intracellular Ca 2+ chelator BAPTA-AM, IP3R inhibitor Xestospongin C (Xesto C), cADPr inhibitor 8-Br-cADPr, and NAADP inhibitor Trans-Ned-19 (T Ned-19) on CCh-induced mucus secretion in ( A ) the SI villus, ( B ) the SI crypt. Effect of Ca 2+ signaling inhibitors on CCh-induced GAP formation in ( C ) the SI villus, ( D ) the SI crypt. ( E–K ) Representative images of the effect of the respective treatments on CCh-induced mucus secretion and GAP formation. Scale bar: E–K = 50 µm. Data are presented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, n.s = non-significant as compared to CCh. Vehicle and CCh, n = 7, EGTA and BAPTA-AM n = 5, Xesto C, T-Ned-19, and 8-Br-cADPr n = 6. Statistical analysis was performed using a one-way ANOVA followed by Dunnet’s post hoc test. Each data point in ( A–D ) represents the average of 25 villi or 40 crypts from one mouse.

    Journal: eLife

    Article Title: Intestinal goblet cells sample and deliver lumenal antigens by regulated endocytic uptake and transcytosis

    doi: 10.7554/eLife.67292

    Figure Lengend Snippet: Effect of the extracellular Ca 2+ chelator EGTA, intracellular Ca 2+ chelator BAPTA-AM, IP3R inhibitor Xestospongin C (Xesto C), cADPr inhibitor 8-Br-cADPr, and NAADP inhibitor Trans-Ned-19 (T Ned-19) on CCh-induced mucus secretion in ( A ) the SI villus, ( B ) the SI crypt. Effect of Ca 2+ signaling inhibitors on CCh-induced GAP formation in ( C ) the SI villus, ( D ) the SI crypt. ( E–K ) Representative images of the effect of the respective treatments on CCh-induced mucus secretion and GAP formation. Scale bar: E–K = 50 µm. Data are presented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, n.s = non-significant as compared to CCh. Vehicle and CCh, n = 7, EGTA and BAPTA-AM n = 5, Xesto C, T-Ned-19, and 8-Br-cADPr n = 6. Statistical analysis was performed using a one-way ANOVA followed by Dunnet’s post hoc test. Each data point in ( A–D ) represents the average of 25 villi or 40 crypts from one mouse.

    Article Snippet: 8-Br-cADPr (0.2 mg/kg) (Sigma-Aldrich, St Louis, MO) and Trans-Ned19 (5 mg/kg) (Tocris, Minneapolis, MN) were administered i.p. 30 min prior to intraluminal injection of TRITC-dextran and LY294002 (4 mg/kg) was administered i.p. 15 min prior to intraluminal injection of TRITC-dextran.

    Techniques:

    Effect of the extracellular Ca 2+ chelator EGTA, intracellular Ca 2+ chelator BAPTA-AM, IP3R inhibitor Xestospongin C (Xesto C), cADPr inhibitor 8-Br-cADPr, and NAADP inhibitor Trans-Ned-19 (T Ned-19) on ( A ) CCh-induced mucus secretion and ( B ) GAP formation in the distal colon. ( C–I ) Representative images of the effect of the respective treatments on CCh-induced mucus secretion and GAP formation. Data are presented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, n.s = non-significant as compared to CCh. Vehicle and CCh, n = 7, EGTA and 8-Br-cADPr n = 5, BAPTA-AM, Xesto C, and T-Ned-19 n = 6. Scale bar: C–I = 50 µm Statistical analysis was performed using a one-way ANOVA followed by Dunnet’s post hoc test. Each data point in ( A–B ) represents the average of 40 crypts from one mouse.

    Journal: eLife

    Article Title: Intestinal goblet cells sample and deliver lumenal antigens by regulated endocytic uptake and transcytosis

    doi: 10.7554/eLife.67292

    Figure Lengend Snippet: Effect of the extracellular Ca 2+ chelator EGTA, intracellular Ca 2+ chelator BAPTA-AM, IP3R inhibitor Xestospongin C (Xesto C), cADPr inhibitor 8-Br-cADPr, and NAADP inhibitor Trans-Ned-19 (T Ned-19) on ( A ) CCh-induced mucus secretion and ( B ) GAP formation in the distal colon. ( C–I ) Representative images of the effect of the respective treatments on CCh-induced mucus secretion and GAP formation. Data are presented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, n.s = non-significant as compared to CCh. Vehicle and CCh, n = 7, EGTA and 8-Br-cADPr n = 5, BAPTA-AM, Xesto C, and T-Ned-19 n = 6. Scale bar: C–I = 50 µm Statistical analysis was performed using a one-way ANOVA followed by Dunnet’s post hoc test. Each data point in ( A–B ) represents the average of 40 crypts from one mouse.

    Article Snippet: 8-Br-cADPr (0.2 mg/kg) (Sigma-Aldrich, St Louis, MO) and Trans-Ned19 (5 mg/kg) (Tocris, Minneapolis, MN) were administered i.p. 30 min prior to intraluminal injection of TRITC-dextran and LY294002 (4 mg/kg) was administered i.p. 15 min prior to intraluminal injection of TRITC-dextran.

    Techniques:

    Journal: eLife

    Article Title: Intestinal goblet cells sample and deliver lumenal antigens by regulated endocytic uptake and transcytosis

    doi: 10.7554/eLife.67292

    Figure Lengend Snippet:

    Article Snippet: 8-Br-cADPr (0.2 mg/kg) (Sigma-Aldrich, St Louis, MO) and Trans-Ned19 (5 mg/kg) (Tocris, Minneapolis, MN) were administered i.p. 30 min prior to intraluminal injection of TRITC-dextran and LY294002 (4 mg/kg) was administered i.p. 15 min prior to intraluminal injection of TRITC-dextran.

    Techniques: Plasmid Preparation, Sequencing, Software